Background: Electroconvulsive therapy is one of the most effective treatments for major depressive disorder. Recently, there has been increasing attention to evaluate the effect of ECT on resting-state functional magnetic resonance imaging. This study aims to compare rs-fMRI of depressive disorder patients with healthy participants, investigate whether pre-ECT dynamic functional network connectivity network estimated from patients rs-fMRI is associated with an eventual ECT outcome, and explore the effect of ECT on brain network states.Method: Resting-state functional magnetic resonance imaging data were (...) collected from 119 patients with depression or depressive disorder, and 61 healthy participants, with an age mean of 52.25 years old. The pre-ECT and post-ECT Hamilton Depression Rating Scale were 25.59 ± 6.14 and 11.48 ± 9.07, respectively. Twenty-four independent components from default mode and cognitive control network were extracted, using group-independent component analysis from pre-ECT and post-ECT rs-fMRI. Then, the sliding window approach was used to estimate the pre-and post-ECT dFNC of each subject. Next, k-means clustering was separately applied to pre-ECT dFNC and post-ECT dFNC to assess three distinct states from each participant. We calculated the amount of time each subject spends in each state, which is called “occupancy rate” or OCR. Next, we compared OCR values between HC and DEP participants. We also calculated the partial correlation between pre-ECT OCRs and HDRS change while controlling for age, gender, and site. Finally, we evaluated the effectiveness of ECT by comparing pre- and post-ECT OCR of DEP and HC participants.Results: The main findings include depressive disorder patients had significantly lower OCR values than the HC group in state 2, where connectivity between cognitive control network and default mode network was relatively higher than other states, Pre-ECT OCR of state, with more negative connectivity between CCN and DMN components, is linked with the HDRS changes. This means that those DEP patients who spent less time in this state showed more HDRS change, and The post-ECT OCR analysis suggested that ECT increased the amount of time DEP patients spent in state 2.Conclusion: Our finding suggests that dynamic functional network connectivity features, estimated from CCN and DMN, show promise as a predictive biomarker of the ECT outcome of DEP patients. Also, this study identifies a possible underlying mechanism associated with the ECT effect on DEP patients. (shrink)

This book's thirty essays explore philosophically the nature and morality of sexual perversion, cybersex, masturbation, homosexuality, contraception, same-sex marriage, promiscuity, pedophilia, date rape, sexual objectification, teacher-student relationships, pornography, and prostitution. Authors include Martha Nussbaum, Thomas Nagel, Alan Goldman, John Finnis, Sallie Tisdale, Robin West, Alan Wertheimer, John Corvino, Cheshire Calhoun, Jerome Neu, and Alan Soble, among others. A valuable resource for sex researchers as well as undergraduate courses in the philosophy of sex.

In this short essay, I report results from a representative national dataset from the Cooperative Institutional Research Program that shows that significantly more men than women intend to major in philosophy at the high-school and pre-university level. This lends credence to pre-university effects hypotheses of women's underrepresentation in philosophy and successfully replicates a smaller analysis performed by Cheshire Calhoun at Colby College in 2009. I also defend my analysis against an objection that claims that intention to major is not (...) a good predictor of final major selection. Finally, I argue that this new analysis should lead to further investment in university-level diversity programs. (shrink)

Drawing on Ezekiel Emanuel’s controversial piece ‘Why I hope to die at 75,’ I distinguish two types of concern in ethical debates about extending the human lifespan. The first focusses on the value of living longer from prudential and social perspectives. The second type of concern, which has received less attention, focusses on the value of aiming for longer life. This distinction, which is overlooked in the ethical literature on life extension, is significant because there are features of human psychology (...) and the structure of a life that should give pause when considering how long one should aim to live, but which do not neatly coincide with considerations about how valuable additional life is likely to be. I argue that, while Emanuel’s case for hoping to die at 75 is unconvincing, he nonetheless provides weak pro tanto considerations in favour of taking a moderate life span as a prudential aim around which to base at least some significant life plans. (shrink)

One of the strongest objections to the development and use of substantially life-extending interventions is that they would exacerbate existing unjust disparities of healthy lifespans between rich and poor members of society. In both popular opinion and ethical theory, this consequence is sometimes thought to justify a ban on life-prolonging technologies. However, the practical and ethical drawbacks of banning receive little attention, and the viability of alternative policies is seldom considered. Moreover, where ethicists do propose alternatives, there is scant effort (...) to consider their merits in light of developing world priorities. In response to these shortcomings, I distinguish four policy options and, on the basis of a plausible intuition about fairness, evaluate their implications for a fair distribution of healthy lifespans. I claim that even in developing nations it would be fairest to favor policies that promote equal access to at least one promising category of substantially life-extending intervention: calorie restriction mimetics. (shrink)

This is a book about sensory states and their apparent characteristics. It confronts a whole series of metaphysical and epistemological questions and presents an argument for type materialism: the view that sensory states are identical with the neural states with which they are correlated. According to type materialism, sensations are only possessed by human beings and members of related biological species; silicon-based androids cannot have sensations. The author rebuts several other rival theories, and explores a number of important issues: the (...) forms and limits of introspective awareness of sensations, the semantic properties of sensory concepts, knowledge of other minds, and unity of consciousness. The book is a significant contribution to the philosophy of mind, and has much to say to psychologists and cognitive scientists. (shrink)

This book presents a comprehensive theory of consciousness. The initial chapter distinguishes six main forms of consciousness and sketches an account of each one. Later chapters focus on phenomenal consciousness, consciousness of, and introspective consciousness. In discussing phenomenal consciousness, Hill develops the representational theory of mind in new directions, arguing that all awareness involves representations, even awareness of qualitative states like pain. He then uses this view to undercut dualistic accounts of qualitative states. Other topics include visual awareness, visual appearances, (...) emotional qualia, and meta-cognitive processing. This important work will interest a wide readership of students and scholars in philosophy of mind and cognitive science. (shrink)

In the first chapter of his Knowledge and Lotteries, John Hawthorne argues that thinkers do not ordinarily know lottery propositions. His arguments depend on claims about the intimate connections between knowledge and assertion, epistemic possibility, practical reasoning, and theoretical reasoning. In this paper, we cast doubt on the proposed connections. We also put forward an alternative picture of belief and reasoning. In particular, we argue that assertion is governed by a Gricean constraint that makes no reference to knowledge, and that (...) practical reasoning has more to do with rational degrees of belief than with states of knowledge. (shrink)

This volume presents a selection of essays by the leading philosopher Christopher S. Hill. Together, they address central philosophical issues related to four key concerns: the nature of truth; the relation between experiences and brain states; the relation between experiences and representational states; and problems concerning knowledge.

There is an important family of semantic notions that we apply to thoughts and to the conceptual constituents of thoughts - as when we say that the thought that the Universe is expanding is true. Thought and World presents a theory of the content of such notions. The theory is largely deflationary in spirit, in the sense that it represents a broad range of semantic notions - including the concept of truth - as being entirely free from substantive metaphysical and (...) empirical presuppositions. At the same time, however, it takes seriously and seeks to explain the intuition that there is a metaphysically or empirically 'deep' relation linking thoughts to reality. Thus, the theory represents a kind of compromise between deflationism and versions of the correspondence theory of truth. This book will appeal to students and professionals interested in the philosophy of logic and language. (shrink)

As the subtitle indicates, this book is concerned with the relationship between consciousness and the physical world. It recommends a novel and disturbingly pessimistic view about this topic that it calls “naturalistic mysterianism.” The view is naturalistic because it maintains that states of consciousness are reducible to physical properties of the brain. It counts as “mysterian” because it asserts that the physical properties in question are entirely beyond our ken—that they lie well beyond the scope of contemporary neuroscience, and quite (...) likely beyond the scope of any body of scientific knowledge that we might develop in the future. Naturalistic mysterianism thus affirms the unity of consciousness with the physical world, while also claiming that the nature of that unity will forever elude us, due to inherent limits of our cognitive capacities. (shrink)

Visual experience is shaped by a number of factors that are independent of the external objects that we perceive—factors like lighting, angle of view, and the sensitivities of photoreceptors in the retina. This paper seeks to catalog, analyze, and explain the fluctuations in visual phenomenology that are due to such factors.

There are two main accounts of what it is for external objects to be presented in visual experience. According to particularism, particular objects are built into the representational contents of experiences. Existentialism is a quite different view. According to existentialism, the representational contents of perceptual experiences are general rather than particular, in the sense that the contents can be fully captured by existentially quantified statements. The present paper is a defense of existentialism. It argues that existentialism is much better equipped (...) than particularism to explain the contents of hallucinations, and it defends existentialism against three objections. (shrink)

There are two main accounts of what it is for external objects to be presented in visual experience. According to particularism, particular objects are built into the representational contents of experiences. Existentialism is a quite different view. According to existentialism, the representational contents of perceptual experiences are general rather than particular, in the sense that the contents can be fully captured by existentially quantified statements. The present paper is a defense of existentialism. It argues that existentialism is much better equipped (...) than particularism to explain the contents of hallucinations, and it defends existentialism against three objections. (shrink)

Schellenberg's book The unity of perception is full of innovative ideas and challenges to preconceptions. This discussion endorses several of Schellenberg's main contentions, but it also challenges her handling of several key topics, such as hallucinations and perceptual awareness of particulars, and it expresses doubts about the informativeness of her main analytic tool, the notion of a perceptual capacity.

The aim of this paper is to distinguish between, and examine, three issues surrounding Humphreys's paradox and interpretation of conditional propensities. The first issue involves the controversy over the interpretation of inverse conditional propensities — conditional propensities in which the conditioned event occurs before the conditioning event. The second issue is the consistency of the dispositional nature of the propensity interpretation and the inversion theorems of the probability calculus, where an inversion theorem is any theorem of probability that makes explicit (...) (or implicit) appeal to a conditional probability and its corresponding inverse conditional probability. The third issue concerns the relationship between the notion of stochastic independence which is supported by the propensity interpretation, and various notions of causal independence. In examining each of these issues, it is argued that the dispositional character of the propensity interpretation provides a consistent and useful interpretation of the probability calculus. (shrink)

Philosophical Issues, Volume 30, Issue 1, Page 175-191, October 2020.

In this book, Christopher Celenza provides an intellectual history of the Italian Renaissance during the long fifteenth century, from c.1350–1525. His book fills a bibliographic gap between Petrarch and Machiavelli and offers clear case studies of contemporary luminaries, including Leonardo Bruni, Poggio Bracciolini, Lorenzo Valla, Marsilio Ficino, Angelo Poliziano, and Pietro Bembo. Integrating sources in Italian and Latin, Celenza focuses on the linked issues of language and philosophy. He also examines the conditions in which Renaissance intellectuals operated in an (...) era before the invention of printing, analyzing reading strategies and showing how texts were consulted, and how new ideas were generated as a result of conversations, both oral and epistolary. The result is a volume that offers a new view on both the history of philosophy and Italian Renaissance intellectual life. It will serve as a key resource for students and scholars of early modern Italian humanism and culture. (shrink)

We present some teaching materials for metaphysics which use the method of introducing issues via puzzles, paradoxes, problems, and conundrums in metaphysics. The method is motivated by the aim to increase student participation and engagement in metaphysical issues so that the student considers and understands philosophical theories based on specific metaphysical concepts. These materials are a result of distilling first and second year undergraduate academic materials into simple presentations that retain the core focus on salient concepts. The presented teaching methods (...) share the same approach as Raymond Smullyan's puzzle-first approach to teaching. Potential goals for the material are numerous; one main goal is the development of the individual student's independent, original, and creative philosophical thinking and analysis as applied to the area of metaphysics. Other goals include the appreciation of overlap between different subareas within metaphysics - overlaps that we note. The article finishes with a further consideration of the importance and utilization of the emotions elicited from materials of philosophical problems and how these can be best incorporated into the teaching methods. (shrink)

My goal is to formulate a theory of introspection that can be integrated with a strongly reductionist account of sensations that I have defended elsewhere. In pursuit of this goal, I offer a skeletal explanation of the metaphysical nature of introspection and I attempt to resolve several of the main questions about the epistemological status of introspective beliefs.

Chalmers’s anti-materialist argument runs as follows.